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Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (3)

Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy of CD4(+) T lymphocytes caused by human T lymphotropic virus type-1 (HTLV-1) infecti......

Advances in minimal residual disease monitoring in multiple myeloma

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (7)

Multiple myeloma (MM) is characterized by the clonal expansion of plasma cells and the excretion of a monoclonal immunoglobulin (M-protein), or fragme......

Emerging applications of machine learning in genomic medicine and healthcare

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; ()

The integration of artificial intelligence technologies has propelled the progress of clinical and genomic medicine in recent years. The significant i......

Laboratory testing for mitochondrial diseases: biomarkers for diagnosis and follow-up

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (4)

The currently available biomarkers generally lack the specificity and sensitivity needed for the diagnosis and follow-up of patients with mitochondria......

Artificial intelligence in serum protein electrophoresis: history, state of the art, and perspective

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; ()

Serum protein electrophoresis (SPEP) is a valuable laboratory test that separates proteins from the blood based on their electrical charge and size. T......

It's in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (8)

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an unprecedented global healthcare crisis. While SARS-CoV-2-a......

Lean and Six Sigma as continuous quality improvement frameworks in the clinical diagnostic laboratory

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (1)

Processes to enhance customer-related services in healthcare organizations are complex and it can be difficult to achieve efficient patient-focused se......

Development of circulating microRNA-based biomarkers for medical decision-making: a friendly reminder of what should NOT be done

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (2)

Circulating cell-free microRNAs (miRNAs) represent a major reservoir for biomarker discovery. Unfortunately, their implementation in clinical practice......

The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (1)

While coronavirus disease 2019 (COVID-19) begins as a respiratory infection, it progresses as a systemic disease involving multiorgan microthromboses ......

DropWise: current role and future perspectives of dried blood spots (DBS), blood microsampling, and their analysis in sports drug testing

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (1)

For decades, blood testing has been an integral part of routine doping controls. The breadth of information contained in blood samples has become cons......

Point of care blood glucose devices in the hospital setting

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (4)

Dysglycemia is common among hospitalized patients. Accurate point-of-care (POC) glucose monitoring is necessary for the safe administration of insulin......

Inherited causes of exocrine pancreatic insufficiency in pediatric patients: clinical presentation and laboratory testing

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (5)

Pediatric patients with exocrine pancreatic insufficiency (EPI) have symptoms that include abdominal pain, weight loss or poor weight gain, malnutriti......

Erroneous potassium results: preanalytical causes, detection, and corrective actions

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (6)

Potassium is one of the most requested laboratory tests. Its level is carefully monitored and maintained in a narrow physiological range. Even slightl......

Pre-analytical conditions and implementation of quality control steps in liquid biopsy analysis

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (8)

Over the last decade, great advancements have been made in the field of liquid biopsy through extensive research and the development of new technologi......

Estimating glomerular filtration rate with new equations: can one size ever fit all?

期刊: CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES, 2023; 60 (7)

Glomerular filtration rate (GFR) is thought to be the best overall indicator of kidney health. On an individual patient basis, a working knowledge of ......

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